There are many answers to this question that don’t necessarily set off the alarms - owner/operator retiring to a fabulous place; this is sadly part of an estate being settled; etc. Then there are the ones that are the non-answers - “going into a different industry” or “moving and don’t want to manage at a distance” - the answers that make you wonder. And you should wonder.
No matter the reason, you want to dive deeper. Is the real reason owner is selling and “retiring” because the pharmacy for sale is no longer bringing in the income it formerly did? Has a Walgreen’s, CVS and/or Walmart moved in down the block and siphoned off most of the prescription (and incidentals) business? Or is just a poorly managed business that could be turned around with a better approach? Regardless of the answer, it is just one piece of the puzzle.